Scenario: You would like to double click and execute .pl perl script files.

Run the following in Windows command prompt:

assoc .pl=PerlScript
ftype PerlScript=C:\Perl64\bin\perl.exe "%1" %*
set PATHEXT=%PATHEXT%;.PL

To allow IO redirection to work properly, you need to import the following Registry key:

Windows Registry Editor Version 5.00

[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Policies\Explorer]
"InheritConsoleHandles"=dword:00000001

Ref: http://stackoverflow.com/questions/4727480/how-do-i-make-my-perl-scripts-act-like-normal-programs-on-windows
This also talks about how to add a drop handler.